Zydalis MD 10mg/20mg is a drug that has tadalafil as its active ingredient for treating erectile dysfunction (ED) problems in men. This drug is used to treat ED, benign prostatic hyperplasia and pulmonary arterial hypertension by allowing more blood to flow into the penile tissue. This drug is manufactured by an Indian company known as Zydus Cadila.
About the Manufacturer
Zydus Cadila is a pharmaceutical company based in India and started its operations in 1952. This company makes different types of pharmaceuticals including animal products and different drug formulations. This is the only drug manufacturer in India that has developed and successfully launched its own drug of curing dyslipidemia resulting from diabetes. This company develops drugs in different formulations like injectables, inhalers, soft capsules, hard capsules, sterile liquids, tablets, transdermal patches, different vaccines and suppositories.
In the year 2011, Zydus Cadila turned into a billion dollar company and is now the fourth largest drug manufacturer in the country. Drugs of different fields of medicine are made here including:
- Anti-cancer medication
- Diabetes medication
- Inflammation drugs
- Pain relieving drugs among others
These pharmaceutical products are shipped worldwide to countries like France, Brazil, the US and South Africa to name but a few.
Tadalafil Clinical Studies
A study was conducted by Michael Nelson and his counterparts termed as tadalafil-sensitive impairment in muscle blood flow in Duchenne Muscular Dystrophy (DMD). This study focused on tadalafil to find out whether it causes a blood flow blockage in people with DMD a condition caused by the mutation of the dystrophin gene. Those with this condition experience wasting or shedding of muscles and there is no treatment for it apart from using corticosteroids.
Patients with DMD do not have the muscle protein “”dystrophin” and this leads to an impairment of nNOS and its process of targeting sarcolemma where the muscles get nitric oxide.
This impairment makes the dystrophic skeletal muscles fail to show reflexes induced by certain exercises. This links the pathogenesis of DMD with a theoretical vascular element. In this study, data was forwarded using the second phenotype and it shown that blood flow in boys with DMD when measured by using Doppler ultrasound of brachial artery did not go up during a mild exercise such as a hand grip.
The role of tadalafil was clearly laid out during this study when it was used an agent that removed hyperaemia in those suffering from DMD in a way of dose dependence. This study showed the effectiveness of PDE5 therapy as an important way to treat muscular disease.
Another study was conducted by Xu Ziqiang and counterparts to unearth the effects of tadalafil on arteriosclerosis of a graft in rats. Tadalafil can be used to regain the functions of the endothelium and as a treatment of arteriosclerosis but no studies had been conducted to know how it affects the arteriosclerosis developed on a grafted tissue.
For this study, male Brow Norway rats were picked to provide aorta grafts to the male Lewis rats. The rats were placed into 3 groups:
- Group 1, the rats were given saline
- Group 2, the rats were given low doses of tadalafil i.e. 0.5 mg per kg as a daily dosage
- Group 3, the rats received high doses of tadalafil i.e. 1 mg per kg every day.
8 weeks after the transplant, the graft was removed and studied using various tests. To test the level of cGMP, the ELISA process was used and the researchers found that the use of tadalafil led to the decrease of aorta thickness. Tadalafil also led to a concentration increase of cGMP and the cGMP-dependant, kinase enzyme in the rats.
How Tadalafil Works
Tadalafil works by stopping the release of the enzyme phosphodiesterase 5 commonly referred to as PDE5. This enzyme breaks down cGMP found in the corpus cavernosum in the penile region. When a man is sexually stimulated, there is an increased flow of blood towards the penis as the arteries are dilated. The dilation of the arteries occurs after the production of Nitric Oxide in the penile tissue. When the Nitric Oxide is produced, more cGMP is released in the corpus cavernosum leading to a relaxation of the penile muscles. PDE5 stops the accumulation of cGMP and its effects and tadalafil inhibits PDE5 to treat ED.
Zydalis MD Effects for ED
This drug has tadalafil as an active ingredient and, therefore, ends all the problems relating to ED, ejaculation disorders and impotency. You can also use tadalafil to treat benign prostatic hyperplasia. Also, men and women can use it when suffering from pulmonary arterial hypertension.
Zydalis MD comes in tablet form and is taken orally. The tablets should be swallowed whole with the help of water. You should only take one tablet per day and you will receive the desired effects. Take one tablet of ZydalIS MD 10 mg or 20 mg one hour before sexual intercourse.
Common side effects include:
- Stomach upsets
- Painful erections
- Back pain
- Some patients report:
- Visual disturbances
- Hearing loss
- Nasal congestion
- Facial flushing
- Never take this drug if you are on:
These drugs acts as liver inducers and will bring down the level of Zydalis MD in the system. Also, don’t take this drug if you are taking other ED drugs.
There are no customer reviews on Zydalis MD and we recommend you not to buy it until we gather credibility about it. Use other tadalafil drugs to control your ED problem for now.
To maintain the effectiveness of this drug, it should be stored in an airtight container within a temperature range of 15 to 30 degrees Celsius.
Price and Availability
You can easily buy this drug since it’s available in many online stores. You can buy Zydalis MD for $1.34 per 10 mg pill. For slow shipping that takes a month, you pay $30 and for fast shipping you pay $60 per shipment.