Duetact is a hypoglycemic product used for the treatment of the pancreatic diabetes type 2. It has two active ingredients Glimepiride and Pioglitazone. These ingredients lower the glucose level in the blood without a risk of hypoglycemia.
A pharmacological action of Duetact happens by means of the increased natural production of insulin. Entering the body, Duetact stimulates a secretion of insulin from the cells of the pancreatic gland. The production of insulin grows at the moment of the increase of the glucose level in the blood.
Unlike the drugs of sulfonylurea, Duetact causes a moderate release of insulin, so that its level does not exceed the rates and patients do not experience a sudden hypoglycemia which may be dangerous. The use of Duetact lowers a need in the application of the additional insulin.
A peculiarity of the active ingredient Pioglitazone is an increased sensitivity of the muscle and fatty tissue to the action of own insulin, so that the uptake of glucose is increased. And so, in combination, glimepiride and Pioglitazone provide more intensive pharmacological action.
Duetact is used as an addition to the low-carb diet for a long-term control of the glucose level. In case of the low efficiency of monotherapy with Duetact, it may be prescribed with Metformin or insulin, but according to the doctor’s recommendation, and in low doses.
In what dose is Duetact used?
Duetact is produced in the tablets for the oral use. The tablets may have a various dose of the active ingredients:
- 30 mg of Pioglitazone and 2 mg of Glimepiride
- 30 mg of Pioglitazone and 4 mg of Glimepiride
To control the glucose level in the blood, the treatment is started from the minimal dose of Duetact 30/2 mg. The tablets are taken once per day, in the morning, before breakfast. In case of a low therapeutic effect, a dose is increased.
It is not recommended to take more than 2 tablet of Duetact 30/4 mf per day because it may cause more intensive reduction of the glucose level in the blood and side effects. The tablets should be taken with a full glass of water. Take enough liquid (at least 6 glasses) within a day.
- Duetact is not prescribed patients with pancreatic diabetes type 1 and patients under 18 years old
- Do not take Duetact if you are diagnosed severe dysfunctions of liver/kidney, intolerance of lactose, leukopenia
- Patients in diabetic coma are prohibited to take Duetact
- If a patient has been prescribed a combined therapy of the pancreatic diabetes type 2, a dose of insulin should be reduced at the beginning of the use of Duetact
- Using ethanol increases a risk of hypoglycemia, and therefore alcohol consumption is not recommended
At the beginning of the treatment, there is a risk of the side effects: dizziness, fatigue, diarrhea, nausea, lower blood pressure, marked lowering of the glucose level.
A control of the side effects of Duetact will help to change the scheme of the treatment or have a symptomatic therapy in time.
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