Cefixime is a semisynthetic antibacterial product from the group of cephalosporin of 3 generation. This is one of the most effective antibiotics of the new generation which affects many pathogenic organisms.
A mechanism of the action of Cefixime consists in the destruction of the membrane (outer shell) of the cells of bad bacteria. During the destruction of the cellular membrane, bacteria lose protective functions and quickly die.
Cefixime antibiotic is well tolerated and seldom causes side effects. Its main advantage is a broad pharmacological action. Unlike cephalosporin of previous generations, Cefixime acts during more than 70 known originators of the infections. It does not kill bacteria but prevents a repeated attack of the infection.
Cefixime is widely used in the treatment of the infectious-inflammatory diseases: exacerbation of chronic bronchitis, pneumonia, pharyngitis, tonsillitis, bacterial sinusitis, cystitis, inflammation of the middle ear, acute intestinal infections, and others.
In what dose is Cefixime used?
A daily dose of Cefixime is 400 mg for adults and children over 12 years old and with the body weight more than 50 kg. A daily dose is used once, in the morning during meals.
If taking a one-time dose of Cefixime 400 mg causes a disorder of the digestion, the daily dose is divided into 2 parts and 200 mg of Cefixime is used 2 times per day with the interval of 10-12 hours.
Children under 12 hours are prescribed suspension. It is better digested and does not irritate the organs of the gastro-intestinal tract. A daily dose of Cefixime for children under 12 years old with the body weight less than 50 kg is 8 mg per 1 kg of the body weight.
A standard course of the antibacterial therapy should last for at least 7 days.
- Patients with diseases of kidneys should lower a daily dose by 25%
- In case of the intolerance of cephalosporin or penicillin, Cefixime is contraindicated
- Children under 6 months should not take Cefixime
- In case of the prolonged use, a normal microflora of intestine and dyspepsia may happen. Do not take Cefixime for more than 14 days, and probiotics should be used in case of a long-term treatment
- The use of Cefixime is possible during pregnancy but only when the expected advantage for a mother exceeds a potential risk for a fetus.
The use of Cefixime may be accompanied by dry mouth, feeling of thirst, diarrhea, nausea, increased level of bilirubin.
All side effects of Cefixime are reversible and completely disappear after the end of the use of the antibiotic. To prevent candidiasis, it is necessary to take antifungal drugs during the use of Cefixime.
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